Protexin Veterinary Synbiotic D-C Daily probiotic and prebiotic capsules for dogs and cats (Pack of 1, 50 Capsules)

Product Information

Walter, J., Armet, A. M., Finlay, B. B. & Shanahan, F. Establishing or exaggerating causality for the gut microbiome: lessons from human microbiota-associated rodents. Cell 180, 221–232 (2020). Liu, L., Li, P., Liu, Y. & Zhang, Y. Efficacy of probiotics and synbiotics in patients with nonalcoholic fatty liver disease: a meta-analysis. Dig. Dis. Sci. 64, 3402–3412 (2019). This meta-analysis highlights the benefits of synbiotics for the hallmarks of non-alcoholic fatty liver disease, liver steatosis, liver enzymes, lipid profiles and liver stiffness. Chang, Y. S. et al. Synbiotics for prevention and treatment of a dermatitis: a meta-analysis of randomized clinical trials. JAMA Pediatr. 170, 236–242 (2016). This meta-analysis provides evidence that supports the use of synbiotics for the treatment of atopic dermatitis, which is thought to be associated with altered gut microbiota that promote an environment that is more susceptible to allergic disease. Childs, C. E. et al. Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. lactis induce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study. Br. J. Nutr. 111, 1945–1956 (2014). Secretaria de Politicas, Regulacion e Institutos, Ministerio de Salud, Argentina. Codigo Alimentario Argentino [Spanish] http://www.anmat.gov.ar/webanmat/Legislacion/Alimentos/Resolucion_Conjunta_261-2011_y_22-2011.pdf (2011).

Government of Canada. Accepted Claims about the Nature of Probiotic Microorganisms in Food https://www.canada.ca/en/health-canada/services/food-nutrition/food-labelling/health-claims/accepted-claims-about-nature-probiotic-microorganisms-food.html (2009). Sergeev, I. N., Aljutaily, T., Walton, G. & Huarte, E. Effects of synbiotic supplement on human gut microbiota, body composition and weight loss in obesity. Nutrients 12, 222 (2020).

Additives

Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115(1):178-181. Aabed, K. et al. Ameliorative effect of probiotics ( Lactobacillus paracaseii and Protexin(R)) and prebiotics (propolis and bee pollen) on clindamycin and propionic acid-induced oxidative stress and altered gut microbiota in a rodent model of autism. Cell Mol. Biol. 65, 1–7 (2019). Probiotics are live microorganisms, prebiotics are nondigestible food ingredients that support resident intestinal bacteria, and synbiotics are a combination of both.

million CFU/g concentration of beneficial bacteria ensures optimum immune system and digestive support. Walker, A. W. & Lawley, T. D. Therapeutic modulation of intestinal dysbiosis. Pharmacol. Res. 69, 75–86 (2013).Regulatory statutes will differ with regard to geographical regions, regulatory categories, types of allowable claims and premarket approval. Furthermore, different standards exist for manufacturing, efficacy and safety depending on geographical region and product category. The term synbiotic does not stipulate a regulatory category, so (simply stated), regulatory requirements for a synbiotic would need to meet those that apply to the category (for example, drug, food or supplement) of the marketed product. Alexander, N. et al. Achieving a transparent, actionable framework for public-private partnerships for food and nutrition research. Am. J. Clin. Nutr. 101, 1359–1363 (2015). Usami, M. et al. Effects of perioperative synbiotic treatment on infectious complications, intestinal integrity, and fecal flora and organic acids in hepatic surgery with or without cirrhosis. J. Parenter. Enter. Nutr. 35, 317–328 (2011). van den Nieuwboer, M. et al. Safety of probiotics and synbiotics in children under 18 years of age. Benef. Microbes 6, 615–630 (2015). Favretto, D. C., Pontin, B. & Moreira, T. R. Effect of the consumption of a cheese enriched with probiotic organisms ( Bifidobacterium lactis Bi-07) in improving symptoms of constipation. Arq. Gastroenterol. 50, 196–201 (2013).